Maternal Syphilis of Unknown Duration: Birth Outcomes in an Immediate Test-and-Treat Cohort often Receiving Fewer than Three Doses of Benzathine Penicillin G.

In a South African antenatal cohort, an immediate test-and-treat model for syphilis of unknown duration showed that adverse birth outcomes-including stillbirth and preterm birth-were similar between women without syphilis and those treated with penicillin, regardless of completion of the three-dose regimen. Further studies are needed to evaluate optimal treatment strategies in pregnancy.