Melanie M Dubois, Mackenzie Powell, Sara Schenkel, Samuel Kgole, Gosego Masasa, Martha Ngwaca, Boitshepo Phale, Nyaladzi C Maphorisa, Terence Mohammed, Sikhulile Moyo, Tuduetso Molefi, Topo Makhondo, Lebalang Mosiane, Sidney O Kololo, Tanvi Sharma, Heather Jaspan, Leslie A Enane, Lisa M Butler, Lucy Mupfumi, Paul Christos, Radhika Sundararajan, Jyoti Mathad, Daniel Fitzgerald, Kathleen Powis
This Botswana-based study evaluated the prevalence of tuberculosis (TB) infection and disease among 50 adolescents, including 25 HIV-exposed uninfected (HEU) and 25 HIV-unexposed uninfected. We found that 12% of adolescents HEU had a positive QuantiFERON-TB Gold Plus test, while no adolescent HIV-unexposed uninfected tested positive. This exploratory study found that adolescents HEU may be at increased risk for TB infection and disease, with larger studies needed.