Resistant hypertension and epileptic seizures: a possible modulatory role of renal denervation-a case report.

BACKGROUND: Renal denervation (RDN) is an emerging therapy for selected patients with resistant hypertension. Its broader autonomic effects may extend beyond blood pressure regulation. CASE SUMMARY: A 57-year-old man with resistant hypertension treated with six antihypertensive drugs and recurrent autonomic and generalized seizures underwent radiofrequency RDN. At 3 months, ambulatory blood pressure monitoring showed sustained improvement (24 h mean 139/87 mmHg), enabling therapy de-escalation. Generalized tonic-clonic seizures resolved, and autonomic/focal events markedly decreased without changes in antiepileptic medication. DISCUSSION: This case illustrates a potential extrapressor effect of RDN mediated by modulation of sympathetic overactivity. Although causality cannot be drawn from a single case, the parallel neurological improvement supports exploring RDN's role in conditions involving autonomic dysregulation, including certain epileptic syndromes.