Supersaturated Oxygen Therapy for Wound Healing: A Comprehensive Review.

Chronic wounds are a major source of patient morbidity and healthcare expenditure, with impaired tissue oxygenation recognized as a notable obstacle to successful repair. Supersaturated oxygen (SSO2) therapies have gained increasing traction as adjunctive treatments to improve the local wound environment and support the healing process. This review examines the current research and applications of SSO2 therapy in wound healing, including its proposed biological effects, methods of administration, clinical outcomes, and safety considerations. Current research suggests that oxygen-enriched therapies may support tissue regeneration through multiple mechanisms, including the promotion of vascularization, support of extracellular matrix formation, optimization of cellular energy production, and modulation of host inflammatory and antimicrobial processes. Clinical studies have also reported improved outcomes in chronic wounds, particularly diabetic foot ulcers, with additional positive findings in venous leg ulcers, pressure ulcers, and select postoperative wounds. Although limitations remain regarding ideal patient selection and long-term financial impacts, current data support SSO2 therapy as a promising adjunctive therapy within comprehensive wound management.