Xenbase: A Guide to the Xenopus Genetics and Genomics Knowledgebase.

Xenbase is the Xenopus frog model organism knowledgebase, an online resource ( www.xenbase.org ) that hosts fully integrated and cross-referenced genomic and biological data to support Xenopus researchers worldwide. Xenbase hosts a vast variety of gene-centric content, including annotated genomes for X. laevis and X. tropicalis, bioinformatic tools for comparative genetic analyses, curated data from published Xenopus research, and reagent catalogues. The homepage features a rotating news and events carousel and a latest content panel. Navigation through the site accommodates different workflows via a quick search menu, a standard top-of-the-page menu bar, or subject tiles, each with links to our interconnected data and resource modules. Here we describe the 12 core Xenbase modules, and how to explore the newest curated data types, including phenotypes, disease models, ChIP-Seq and RNA-Seq data. We also preview new features and describe new tools and functionality. Additionally, we provide guidelines on how authors can ensure their published data are curatable and FAIR, discuss gene nomenclature, and outline the steps by which researchers can contribute gene expression images, protocols, and GO curations of Xenopus genes.