David Yu Yuan, Alisha Ahamed, Awais Athar, D. Rajkumar, Gupta Dipayan, Muhammad Haseeb, Ihsan Maira, Ivanov Eugene, Kadhirvelu Vishnukumar, Khen Amnon, Manish Kumar, Ankur Lathi, Isuru Liyanage, Meszaros Lili, Colman O’Cathail, Joana Paupério, Paz Ruben, Pesant Stephane, Rahman Nadim, Jeena Rajan, Tutis Iva, Ventouratou Marianna, Vijayaraja Senthilnathan, Waheed K. Zahra, W. Brewer Peter, Tony Burdett, Guy Cochrane, Sarkans Ugis
The European Nucleotide Archive (ENA; https://www.ebi.ac.uk/ena), hosted at the European Molecular Biology Laboratory's European Bioinformatics Institute (EMBL-EBI), remains a global, open-access platform for the submission, archiving, dissemination, and reuse of nucleotide sequence data. In 2025, ENA continues to advance its mission of fostering FAIR (findable, accessible, interoperable, reusable) data principles through innovations in interoperability, scalability, and global engagement, providing infrastructure for a rapidly growing volume of data across diverse domains. This article highlights the key developments in 2025, including the progress of the technical transformation, enhanced support for large-scale biodiversity projects, and the implementation of the International Nucleotide Sequence Database Collaboration Global Participation Initiative. We also discuss infrastructure enhancements to handle exponential data growth and improve user experiences and data discovery.