Design and evaluation of an amphiphilic biaryl ether library using a novel cell-based β-arrestin recruitment assay for the octopamine receptors of Balanus improvisus.
Karoline Nordli, Jonne Laurila, Jørn H Hansen
原始摘要（英文原文）· Original abstract
A 22-compound amphiphilic biaryl ether library inspired by the antifouling compound medetomidine has been designed and synthesized. The compound library was evaluated in a primary screening using a novel β-arrestin assay in CHO cells expressing the BiOctα-octopamine receptor of Balanus improvisus. One new compound was found to act as a weak agonist on both BiOctα octopamine receptor and human α2A-adrenoceptors.
Design and evaluation of an amphiphilic biaryl ether library using a novel cell-based β-arrestin recruitment assay for the octopamine receptors of Balanus improvisus. — 科研速览 Science Skim