Fan Bai, Xinglong Zhang, Yongxu Fu, Hongliang Lu, Fei Li, E Andrew Bennett, Shuwen Pei, Peng Cao, Qingyan Dai, Feng Liu, Xiaotian Feng, Ming Zhang, Wenjun Wang, Fajun Li, Ganyu Zhang, Wanjing Ping, Tianxiang Liu, Qiaomei Fu
HUC-MSCs restore immune homeostasis in aging frailty through sequential, multi-faceted immunomodulation. The association between specific immune remodeling features and functional recovery positions HUC-MSCs as a promising mechanism-based therapy for aging frailty.
Southwestern East Asia, a key intersection linking southern East Asia, Southeast Asia, and the Tibetan Plateau, is a crucial area for the study of early human migrations. However, ancient DNA studies in the eastern part of the region, particularly in Guizhou, are still lacking. We present the first genomic study of Guizhou populations from a time period spanning 12 000 years, including five Guizhou individuals older than 10 000 years. Combined with published Guangxi and Yunnan samples, we reveal a complex genetic history of human populations in southwestern East Asia from the Paleolithic to the Early Neolithic periods. Paleolithic populations were marked by heterogeneous distribution patterns of the recently described basal East Asian Xingyi_EN ancestry admixed with ancestry present in northern East Asia. By the Bronze Age, this enigmatic basal ancestry was no longer detectable in the region. Beginning 1200 years ago, genetic interactions between Guizhou and Guangxi populations intensified following language-specific patterns. Overall, our results clarify the complex population dynamics of southwestern East Asia over the past 12 000 years.