Aging Biomarker Consortium, Xiaoyan Zhang, Anqun Chen, Linli Lv, Liang Ma, Yan Zheng, Beibei Ma, Ziying Zhong, Yaobin Jing, Aiming Qiu, Yunxia Shao, Weiqi Zhang, Jun Cen, Lili Zhou, Wei Chen, Chun Zhang, Jian Li, Jing Chen, Baoxue Yang, Youhua Liu, Jing Qu, Fan Yi, Jinghong Zhao, Bi-Cheng Liu, Xiong Zhong Ruan, Limin Lu, Feng Zheng, Guang-Hui Liu, Gang Pei, Jing Nie, Youfei Guan
Renal aging involves structural and functional kidney decline (reduced size/nephrons, glomerulosclerosis, tubular atrophy, functional loss) and is an independent risk factor for kidney and systemic degenerative diseases. On 16 May 2025, the Aging Biomarker Consortium convened an expert consensus meeting in Shanghai, proposing a multidimensional biomarker framework: functional (estimated glomerular filtration rate, renal blood flow), structural (renal volume loss), and humoral (Klotho, N-terminal Pro-B-type natriuretic peptide, senescence-associated secretory phenotype factors). The consensus also supports machine-learning models for biological age assessment and calls for multi-center cohorts and translational collaboration to improve elderly kidney health.