Nina Ajmone Marsan, Jeroen J Bax
A conceptual framework illustrating the optimal therapeutic window of TTVR across the spectrum of TR severity. A schematic curve plotting expected clinical benefit (y-axis) against TR severity (x-axis) demonstrates a peak around massive TR, declining as torrential TR is accompanied by RV dysfunction. A shaded region marks the ‘sweet spot for TTVR’, with annotations highlighting the distinction of reversible RV dilatation vs irreversible RV dysfunction.