Furio Colivicchi, Pier Luigi Temporelli, Francesco Fattirolli, Maurizio Giuseppe Abrignani, Alessandro Alonzo, Marcello Arca, Maurizio Averna, Daniele Bertoli, Paolo Calabrò, Leonardo Calò, S Carugo, Alberico Luigi Catapano, Martina Ceseri, Stefania Angela Di Fusco, Andrea Di Lenarda, G. Fabbri, Michele Massimo Gulizia, Giuseppe La Rosa, Donata Lucci, Simone Maffei, Alessandro Navazio, Fabrizio Oliva, Francesco Orso, Carmine Riccio, Nicola Scelza, Domenico Gabrielli, Aldo Pietro Maggioni, BRING-UP Prevention, Furio Colivicchi, Aldo P Maggioni, Maurizio Giuseppe Abrignani, Marcello Arca, Maurizio Averna, Alberico Luigi Catapano, Stefania Angela Di Fusco, Andrea Di Lenarda, Francesco Fattirolli, Domenico Gabrielli, Michele Massimo Gulizia, Fabrizio Oliva, Carmine Riccio, Pier Luigi Temporelli, Martina Ceseri, G. Fabbri, G Orsini, Donata Lucci, Lucio Gonzini, Francesca Bianchini, Ester Mercedes Baldini, Laura Sarti, Furio Colivicchi, Stefania Angela Di Fusco, Alessandro Alonzo, Alessandro Aiello, S Carugo, Lucia Barbieri, Valeria Borrelli, Francesco Manca, Stefano Righini, Angelo Palermo, Paolo Calabrò, Arturo Cesaro, Carmine Riccio, Leonardo Calò, Germana Panattoni, Ilaria Jacomelli, Nicola Vitulano, Maria Scarcia, V Perniciaro, Giuliana Mombelli, Francesco Vicari, Antonia Alberti, I Smecca, Giuseppe Schembri, Manuela Stancampiano, Rita Cristina Myriam Intravaia, Alessandro Maloberti, Chiara Tognola, Marina Delfini, Stefano Iosi, Maria Chiara Gatto, Francesca Moschella Orsini, Giuseppe La Rosa, Antonio Cafà, Gerardo De Mitri, Benedetta Veronesi, Lidia Rossi, Leonardo Grisafi, Michele Emdin, Alberto Aimo, Simone Calcagno, Giulio Luciani, Eduardo Capuano, Chiara Iannarella, Emilio Di Lorenzo, Francesca Lanni, Francesco Greco, Saverio Alberti, Giulia Ricci Lucchi, Matteo Schinzari
AIMS: Adherence to guideline recommendations for secondary prevention appears to be inadequate, even in cardiology centres. To narrow the gap between guideline recommendations and what is implemented in clinical practice, we designed the BRING-UP Prevention project. METHODS AND RESULTS: BRING-UP Prevention is a nationwide, observational, prospective, multicenter study enrolling patients with a prior atherothrombotic event. The study consists of two 3-month enrolment phases followed by a 6-month follow-up, with each phase preceded by an educational intervention. Data presented here mainly focus on the percentage of patients at goal for LDL-cholesterol (LDL-C) (<55 mg/dL) at the 6-month follow-up in the recently completed first enrolment phase. Secondary endpoints are blood pressure, glycaemic and weight control, and smoking cessation. Over 3 months, 189 cardiology centres recruited 4790 patients. Follow-up data at 6 months were available for 4643 patients (97%) and LDL-C was available for 4334 of them. The rate of patients with LDL-C < 55 mg/dL increased from 33% to 58.1%, with absolute and relative increases of 25.1% and 76.1%, respectively. At 6 months, 94.9% of patients were prescribed statins. Atorvastatin and rosuvastatin were the most prescribed statins, mostly at high doses. Ezetimibe was prescribed in 84% of cases. PCSK9i monoclonal antibodies and inclisiran were prescribed in 8.3% of patients. CONCLUSION: BRING-UP prevention achieved its primary goal to increase the percentage of patients at the LDL-C goal, demonstrating that, in many patients, this goal can be achieved by increasing the use of low-cost therapies. CLINICALTRIAL.GOV: NCT06275113.