Applicability of LDL-cholesterol calculation formulas in hypertriglyceridemia: Insights from the Vojvodina.

BACKGROUND: Low-density lipoproteins cholesterol (LDL-C) is a key parameter for assessing the risk of atherosclerotic cardiovascular disease. Direct measurement of LDL-C is not always possible due to practical or financial reasons, making the use of calculation formulas essential. The aim of this study was to evaluate the applicability of four different formulas proposed by Friedewald, Sampson, Anandaraja, and Martin-Hopkins for calculating LDL-C compared to direct method in patients with serum triglyceride levels from 4.5 to 9.0 mmol/L in the population of Vojvodina. METHODS: The retrospective study included 272 subjects whose lipid status parameters were measured between June 2022 and June 2023. LDL-C was determined by the direct method (d-LDL-C) on the Alinity c analyser (Abbott Laboratories, Illinois, USA). Calculated LDL-C values were obtained using the four selected formulas.