Saima Aslam, Aleah Brubaker, Mita Shah, Thomas C S Martin, Tyler Mandt, Austin-Marley Windham-Herman, Haiyan Zhang, Tina Bryde, Yilmaz Emre Gençay, Aurelie Gram, Christian Grøndahl, Jakob Krause Haaber, Björn Hallström, Eric van der Helm, Jonas Hink, Lorrie Maccario, Anders Østergaard, Alice Troy, Niloofar Yavari, Robert T Schooley, Sanjay Mehta
We report the first use of adjunctive bacteriophage therapy for Escherichia coli related malakoplakia in a kidney transplant recipient with progressive disease. Adjunctive CRISPR-enhanced phage cocktail SNIPR001 combined with prolonged antibiotics, ascorbic acid, and bethanechol was associated with cutaneous lesion resolution and sustained radiographic regression without phage-related adverse events.