Association between fasting serum uric acid levels and Alzheimer's disease in nursing home residents: a cross-sectional study.

INTRODUCTION: Evidence regarding the association between fasting serum uric acid (FSUA) and Alzheimer's disease (AD) is limited and inconsistent. This study investigated the association between FSUA levels and AD. METHODS: In this cross-sectional study, 852 participants from a hospital specializing in geriatric care were enrolled. Multivariable logistic regression analysis, restricted cubic spline curves, and subgroup analyses were employed to analyze the association between FSUA and AD. RESULTS: The average age of eligible participants was 81.0 ± 8.8 years; 23% were patients with AD and 33.7% were male. Multivariate logistic regression analysis revealed an inverse relationship between FSUA levels and AD. Specifically, a 10 μmol/L increase in FSUA was associated with a 5% decrease in AD odds (OR, 0.95; 95% confidence interval [CI], 0.93-0.97). When FSUA levels were divided into quartiles, the higher quartiles showed progressively lower odds of developing AD than those in the lowest quartiles (p for trend < 0.001). No interactions were observed between FSUA and AD. Restricted cubic spline regression model demonstrated a linear inverse association between the odds of AD and FSUA levels. CONCLUSION: We observed a negative association between FSUA levels and AD. Further prospective studies are required to confirm this causal relationship.