Lan Wang, Ruoqi Zheng, Zichen Li, Leiliang Zhang
Recent increases in cases of western equine encephalitis (WEE) in South America have raised significant concerns about the virus's potential to cause an endemic disease due to its adaptation to mosquito vectors. Currently, there are no effective vaccines or treatments for WEEV, despite ongoing research into various biochemical products in animal models. The virus presents different pathological effects depending on the host. In humans, WEEV infection leads to central nervous system damage, resulting in encephalitis and severe neurological sequelae, which underscores the need for further research into its pathogenic mechanisms. To enhance understanding of WEEV and address potential threats, this review focuses on the virus's natural transmission cycle, the development of biochemical products for combating WEEV infection, and new diagnosis methods. It also highlights research on mechanisms in animal models, offering potential strategies for defending against WEEV.