Wang Xujiu, Zhengkun Li
CONTEXT: With the increasing incidence rate of type II diabetes, it is particularly important to study its potential molecular mechanism and intervention means. Protein tyrosine phosphatase 1B (PTP1B) plays a crucial role in insulin signalling and lipid metabolism. OBJECTIVE: The purpose of this study was to explore the effect of PTP1B protein macromolecule on lipid metabolism in type II diabetes patients under the intervention of aerobic exercise. MATERIALS AND METHODS: The subjects were type II diabetes patients who had undergone aerobic exercise intervention. There were no significant abnormalities in liver and kidney function, indicating the safety of the intervention method. Therefore, PTP1B plays an important role in the regulation of lipid metabolism in type II diabetes. CONCLUSION: Aerobic exercise, as an effective intervention, can significantly improve the lipid metabolism in type II diabetes patients by affecting the function of PTP1B, thus providing new ideas and methods for clinical treatment.