Revisiting the <i>Six Human-Centered Artificial Intelligence Grand Challenges</i> in the Age of Generative AI

Generative AI (GenAI) has shifted AI capabilities from discriminative prediction to creative interaction, offering opportunities to augment productivity and innovation. However, realizing these benefits requires navigating risks where development outpaces governance. This article revisits the Six Human-Centered AI (HCAI) Grand Challenges to analyze their relevance in the generative era. Critical new requirements are identified: preserving human autonomy, ensuring operational safety against non-deterministic outputs, and navigating complex intellectual property landscapes. These findings are synthesized into an updated, actionable research agenda for each challenge, serving as a call to action to operationalize these principles. By shifting focus from risk mitigation to human empowerment, this agenda establishes human-centeredness as the organizing principle for a future where GenAI enhances human agency, dignity, and collective flourishing.