Guomin decoction ameliorates atopic dermatitis by restoring M1/M2 macrophage polarization balance via dual regulation of MAPK/NF-κB and JAK-STAT pathways.

This study investigates the therapeutic effects and mechanisms of Guomin decoction (GMJ) on atopic dermatitis (AD). Animal and cellular experiments revealed that GMJ reduces ear swelling and collagen loss in AD-affected mice, modulates inflammatory factors, and inhibits M1 polarization while promoting M2 polarization. Mechanistic studies indicate that GMJ restores the M1/M2 balance in macrophages by dual regulation of the MAPK/NF-κB and JAK-STAT pathways, thereby improving AD.