Mohammed Alkandari, Meshari Alkandari, Gamal Abdel Nasser Atia, Eman Abd El-Halim, Mohamed Mohamady Ghobashy, Hany K. Shalaby, Dinesh Rokaya, Tarek Foda, Khaled Abd El Khaliq Hendy, Danishuddin, Azizul Haque
Periodontitis causes severe tissue loss, making predictable regeneration a major challenge. Growth factor-loaded chitosan scaffolds offer a promising, multifunctional approach to enhance tissue regeneration. This review explores their design, optimization, and therapeutic potential, focusing on delivery methods, release kinetics, and biocompatibility. Studies show these scaffolds improve local delivery, sustain growth factor release, and reduce cytotoxicity while offering reinforcement and encouraging cell adhesion. Optimized release kinetics ensure a favorable prognosis, reducing the necessity for recurrent administration. Growth factor-loaded chitosan scaffolds create a biomimetic environment that supports periodontal healing, representing an innovative strategy for advancing periodontal therapy. Further research on scaffold design, growth factor combinations, and long-term outcomes is essential to refine this approach for more effective, predictable regeneration.