J‑shaped link of stress hyperglycemia ratio with in-hospital and 1- year mortality in hypertension patients: based on the MIMIC-IV database.

BACKGROUND: Stress hyperglycemia ratio (SHR) is notably linked with unfavorable prognoses. Nevertheless, this correlation in hypertension is elusive. This paper uncovered a link of SHR with mortality in hypertension populations. METHODS: Hypertension patients in ICUs were enrolled from the MIMIC database. The outcomes assessed encompassed in-hospital and 1-year death. SHR was categorized into four groups, and its connection with mortality was assessed using Cox regression analysis. The restricted cubic spline method was leveraged to appraise the non-linear link of SHR with mortality. RESULTS: 2088 patients were enrolled, with 8.67% of in-hospital and 19.92% of 1-year mortality. As a continuous variable, each one-unit enhancement in SHR was connected with an elevation in in-hospital (HR, 1.93 [95% CI: 1.50-2.47]) and 1-year deaths (HR, 1.66 [95% CI: 1.37-2.01]); SHR as a categorical variable, the Q4 group exhibited enhanced in-hospital (HR, 3.29 [95% CI: 1.89-5.74]) and 1-year death (HR, 1.74 [95% CI: 1.29-2.35]). There was a J-shaped connection of SHR with in-hospital and 1-year deaths. CONCLUSION: SHR index can predict in-hospital and 1-year deaths in individuals with critical hypertension.