◆ Avian pathology : journal of the W.V.P.A2026-09-11
The Hcp2b protein of APEC induces defective autophagy in HD11 cells by causing lysosomal dysfunction.
Yaqin Tian, Liting Lu, Shuhui Wang, Jingwen Zhang, Mei Xue, Jiumeng Sun, Ying Shao, Zhengyu Wang, Mengling Peng, Jian Tu, Xiangjun Song
原始摘要（英文原文）· Original abstract
APEC Hcp2b protein translocates into HD11 cells and induces significant cytotoxicity.Hcp2b elicits incomplete autophagy, characterized by blocked autophagic flux.Proteomic analysis demonstrated Hcp2b impairs lysosomes, blocking autophagy.