Resveratrol may mitigate the proliferation and migration of hypertrophic scars <i>via</i> miR-1290/ADAMTS8

Hypertrophic scars (HS) represent a common complication arising from abnormal wound healing following skin injury. Resveratrol and microRNA (miRNA) have been implicated in the formation of HS. However, the precise mechanism by which resveratrol modulates hypertrophic scarring through miRNA regulation remains unclear.Investigating the potential functional effects and molecular mechanisms of resveratrol in HS.RT-qPCR was employed to detect the levels of miR-1290 and ADAMTS8. The targeted binding relationship between miR-1290 and ADAMTS8 was validated through dual luciferase reporter assays and RIP experiments. Cell proliferation, migration capacity, and inflammatory cytokine (IL-1β, IL-6) secretion levels were assessed using CCK-8 assays, Transwell migration assays, and ELISA.MiR-1290 was overexpressed in HS tissue and HSFB cells, whereas ADAMTS8 levels were markedly downregulated, exhibiting a negative correlation between the two. Resveratrol concentration-dependently inhibited miR-1290 levels and upregulated ADAMTS8 levels. ADAMTS8 may represent a direct target gene of miR-1290. Resveratrol may suppress the proliferation, migration, inflammatory cytokine levels, and fibrosis marker levels in HSFB cells. Overexpression of miR-1290 partially reversed the effects of resveratrol, whilst overexpression of ADAMTS8 suppressed the actions induced by miR-1290.Resveratrol may suppress the malignant phenotype of HSFB cells by regulating the miR-1290/ADAMTS8 axis.