Catheter ablation outcomes in monozygotic twins with Wolff-Parkinson-White syndrome and novel TTN/LRP6 variants

BACKGROUND: Genetic associations with isolated sporadic Wolff-Parkinson-White syndrome have rarely been reported. We report a rare case of monozygotic twin male children diagnosed with Wolff-Parkinson-White syndrome. METHODS AND RESULTS: Electrophysiological mapping of the monozygotic twin male children revealed an identical accessory pathway located 1 o'clock anterior to the mitral annulus, which were successfully blocked by radiofrequency ablation. Whole-genome sequencing analysis of the monozygotic twin revealed heterozygous mutations in the TTN and LRP6 genes. CONCLUSIONS: These findings highlight the potential role of genetic factors in the development of sporadic Wolff-Parkinson-White syndrome and may contribute to a better understanding of disease mechanisms and the development of treatment strategies.