Yujia Wang, Guijin Zou, Huajian Gao
Mechanics has historically been a cornerstone of modern science and technology, serving as a vital bridge between science and engineering. In the current era of rapid technological advance, mechanics faces unprecedented challenges and opportunities that demand a paradigm shift in its intellectual framework. Here, we introduce the Mechano-X paradigm—a forward-looking vision for mechanics-based interdisciplinary innovation. In this paradigm, mechanics is not merely a descriptive tool, but an active driver that deeply integrates with other scientific disciplines, enabling the controlled regulation, programming, and optimization of target systems in fields such as materials science, chemistry, biology, and medicine. This proactive integration has already catalyzed transformative fields such as mechanobiology, mechanochemistry, and mechanomaterials. By enabling the design of materials and systems with unprecedented forms, functions, and responsiveness, Mechano-X fosters deep cross-disciplinary convergence. We argue that this integrative approach reaffirms mechanics as a core scientific force, uniquely positioned to inspire the next generation of scientific discovery and technological innovation.