Recent Advances in the Synthesis of Axially Chiral Cycloalkanes

Abstract Axially chiral cycloalkanes have recently emerged as compelling scaffolds with broad utility in asymmetric catalysis and molecular design. This graphical review provides a concise overview of synthetic strategies for constructing axially chiral cycloalkanes. Representative methods summarized include asymmetric allylic substitution, alkene insertion, carbene cross-coupling, carbonyl condensation/reduction, [2+2] cycloaddition, and deracemization. We offer fundamental insights into this emerging field, aiming to facilitate future research toward novel chiral frameworks.