Nathan Martin, Roberto Doville, Lou-Anne Beghin, Anaïs Lachemet, Thomas Beaugrand, Eric Deniau, Lydie Pélinski, Till Bousquet
An efficient method for the synthesis of 3-substituted isoindolinones is described. The addition of a carbamoyl group from carbamoyl-dihydropyridine onto 3-methylene isoindolinones provides amide functionalization under visible light irradiation, in the presence of an organic photocatalyst. This protocol offers mild reaction conditions, a broad substrate scope, and an excellent functional group tolerance, affording a range of structurally diverse 3-amido isoindolinones in good to excellent yields.