Unlocking peptoid diversity through post-functionalizable chiral scaffolds, via modular, divergent and side-chain protecting-group-free synthesis.
Ludovica Dei, Lucio Di Nicola, Luca Gherardi, Fabiana Cordella, Gennaro Pescitelli, Gaetano Angelici
原始摘要（英文原文）· Original abstract
A side-chain protecting-group-free synthesis of a novel class of chiral peptoids, derived from readily available homoserine lactone side chains, is described. This straightforward and modular approach enables post-functionalization of the oligomers via lactone ring-opening with various nucleophiles, thereby facilitating the generation of diverse molecular libraries.