◆ Chemical communications (Cambridge, England)2026-09-23
A self-powered biosensing platform for U937 cell detection and the induction of mitochondrial aggregation.
Wenwen Xu, Yalong Qiao, Qiuting Wang, Lei Feng, Pinghua Ling
原始摘要（英文原文）· Original abstract
An EBFC platform was developed for U937 cell detection via aptamer-triggered glucose oxidation. The generated electrons reduced cathode Fe3+, disrupting an alginate hydrogel to release mitochondrial-targeting nanoparticles. Intracellularly, ATP-induced DNA hybridization caused mitochondrial aggregation and ROS-mediated intervention, achieving closed-loop cancer diagnostics and intervention.