Domino transformation of silylated enamidonitriles for straightforward access to fully substituted 2,3-diaminofuran derivatives.

Herein, we report an efficient three-step domino synthesis of diverse polysubstituted 2,3-diaminofurans from silylated enamidonitriles in good to excellent yields. The process exploits both vinylsilane and acrylonitrile functionalities, enabling in situ substitution of the newly formed 2-amino group and overcoming the intrinsic instability of unsubstituted aminofurans.