Sangram Keshari Panda, Bhavya Khaitan, Shikha Gandhi
2,4-Dienyl sulfones are highly significant moieties in organic synthesis. While the conventional methods for their synthesis rely on the 'leaving-group' strategy to introduce the sulfonyl group and hence reducing the atom-economy of the reaction, we, herein, disclose the use of skipped enynes and cyclopropyl alkynes in a highly atom-economical Pd/Brønsted acid catalyzed synthesis of 2,4-dienyl sulfones. Stable and easy-to-handle sulfonyl hydrazides have been employed as S-pronucleophiles. The reaction demonstrates a wide substrate scope and high stereoselectivity.