◆ Chemical communications (Cambridge, England)2026-09-07
Unlocking the hidden DNAzyme repertoire through aptamer-gated exonuclease signal amplification.
Shusen Xiao, Kai Niu, Yangyang Chang, Zijie Zhang, Hong Yuan, Rui Zhang, Ying Zhang, Rudi Liu, Jiuxing Li, Meng Liu
原始摘要（英文原文）· Original abstract
We present an aptamer-gated exonuclease signal amplification (AGESA) strategy decoupling target recognition from DNAzyme activation to overcome background limitations, enabling selective detection of platelet-derived growth factor BB in urine and unlocking the DNAzyme repertoire for protein biomarkers.