Photo-triggered self-catalyzed construction of perfluoroalkylated quinoxalino[2,1-b]quinazolinones from 3-(2-isocyanophenyl)quinazolinones.

A photo-triggered self-catalyzed perfluoroalkylation/cyclization of 3-(2-isocyanophenyl)quinazolinones for the construction of perfluoroalkylated quinoxalino[2,1-b]quinazolinones was developed using perfluoroiodoalkanes as the perfluoroalkyl radical source. 3-(2-Isocyanophenyl)quinazolinones functioned as both the substrate and the photocatalyst to trigger the cleavage of the C-I bond in perfluoroiodoalkanes to form perfluoroalkyl radicals via energy transfer. This reaction features mild conditions and operational simplicity.