Sukanya Neogi, Alakananda Hajra
An efficacious approach for the three-component direct silylheteroarylation of alkenes via remote C-H functionalization of 8-aminoquinoline amides by synergistic Fe/Ru catalysis has been established. This approach expands the chemical space of complex organosilicon compounds in a cost-effective and step-economic way since it does not require prefunctionalization of heteroarenes and additional synthetic steps to prepare sensitive silylating precursors. Investigation into the reaction mechanisms suggests that the reaction follows a radical route, in addition to ortho-C-H activation of the aromatic ring.