Pd-catalyzed regioselective hydrofluoroallylation of trifluoromethylalkenes with gem-difluorocyclopropanes.

A palladium-catalyzed ring-opening reaction of gem-difluorocyclopropanes was developed to enable selective hydrofluoroallylation of trifluoromethylalkenes without defluorination. This reaction involves C-C bond activation and C-F bond cleavage, and the subsequent hydrofluoroallylation provides structurally diverse fluorinated products bearing both monofluoroalkene and trifluoroalkane motifs.