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◆ Chemical communications (Cambridge, England)2026-08-26

Metal-free electrosynthesis of dihydro-1,3-benzoxazines through multi-component coupling.

Pintu Kumbhakar, Sourav Chandra, Pooja Bhardwaj, Sujon Mondal, Suman De Sarkar

原始摘要(英文原文)· Original abstract
An electrochemical approach for the synthesis of dihydro-1,3-benzoxazines via oxidative sp3 C-H functionalization is described. The method operates under mild conditions and is compatible with a broad range of 2-naphthols and secondary alkylamines, providing rapid access to structurally diverse products in good yields. Mechanistic studies suggest the formation of a key adduct, followed by a TEMPO-mediated oxidation-annulation sequence.
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Metal-free electrosynthesis of dihydro-1,3-benzoxazines through multi-component coupling. — 科研速览 Science Skim