Minimalist covalent organic polymers for delivery of functional DNA cargo in mammalian cells.

Minimalist covalent organic polymers (COPs) enabled intracellular delivery of fluorescently labelled double-stranded DNA cargoes in live mammalian cells. Uptake-associated signals were observed for cargoes of different lengths and architectures, including fluorescent probes and an MMAE-linked cytotoxic construct that retained biological activity after delivery.