Chunyu Zhao, Hanqing Yu, Jing Lyu, Josie Ward, Lucy Boyi Wang, Qiang Geng, Yuxin Jin, Runqi Zhu, Yufeng Tian, Javier Maisueche, Caiqi Shen, Rijian Song, Wenxin Wang
A cationic injectable hydrogel was constructed from thiolated hyaluronic acid and acrylate-functionalised hyperbranched poly(ethylene glycol) via thiol-Michael addition, with covalently immobilised quaternary ammonium groups. The resulting network showed rapid gelation within 27-45 s, tuneable wet-tissue sealing, enzyme-responsive wet-mass loss, enhanced red blood cell retention and good cytocompatibility after network formation.