Programmable magnetic bioactivation: alternating fields as remote controllers of regenerative signaling.

Alternating magnetic fields (AMFs) are emerging as a uniquely versatile modality for remotely programming regenerative biology through deep-penetrating, wireless, and temporally precise actuation. Beyond their conventional role in magnetic hyperthermia, AMFs can be engineered to operate within sub-thermal and non-thermal regimes, where they transduce magnetic energy into biologically instructive thermal, mechanical, and electrical cues. At the mechanistic level, magnetothermal bioactivation induces localized microheating that gates thermosensitive ion channels such as TRPV1, triggering Ca2+-dependent signalling cascades that regulate gene expression, metabolism, and tissue remodelling. In parallel, magnetomechanical stimulation converts oscillatory magnetic fields into nanoscale torque and strain, activating mechanosensitive pathways including Piezo1 and downstream FAK-YAP/TAZ signalling to reinforce cytoskeletal organization and lineage commitment. Complementing these effects, magnetoelectric transduction enables the direct conversion of magnetic inputs into localized electric polarization, modulating membrane potential and engaging voltage-gated ion channels without bulk heating. By coupling wireless stimulation with therapeutic cargo delivery and dynamic microenvironmental modulation, AMF-responsive systems redefine biomaterials as programmable regenerative interfaces.