◆ Chemical communications (Cambridge, England)2026-08-31
A TrxR2-targeted photosensitizer for controlled mitochondrial protein degradation and pyroptosis activation.
Mingwan Shi, Linfei Fu, Peng Gao, Wei Pan, Na Li, Bo Tang
原始摘要（英文原文）· Original abstract
A TrxR2-targeted photosensitizer (HCCU) was developed for mitochondrial protein-targeted photodynamic degradation and pyroptosis activation. Upon laser irradiation, HCCU-generated ROS efficiently degraded mitochondrial TrxR2, inducing mitochondrial collapse and activating Caspase-3/GSDME-mediated tumor pyroptosis.