Hasitieer Bahetibieke, Yansong Zhang, Xia Zhang, Jiawen Ye, Lu Wang, Sicheng Tang, Xingjie Zan, Hao Chen
A compact sequence-defined repetitive peptide, (CYR)3, was designed for ocular plasmid DNA delivery. Integrating cationic, aromatic, and cysteine residues (CYR)3 condenses plasmids into near-neutral biocompatible nanoparticles, achieving efficient intracellular transport, functional anti-angiogenic therapy in vitro, and preliminary in vivo topical corneal transfection.