Yurao Liu, Qianqian Yang, Ling Zhang, Qiyue Lu, Yuhang Li, Haisong Zhang, Chunfang Zhang, Pingli Wu
evaluation results show that this hydrogel can effectively alleviate oxidative stress, accelerating cell migration, proliferation, and angiogenesis. Transcriptome sequencing analysis further revealed that its pro-healing effects are mechanistically associated with key signaling pathways, especially PI3K-AKT and PPAR signaling pathways, to facilitate cell proliferation and suppress inflammation. Overall, the hydrogel provides a straightforward but effective platform for chronic diabetic wound healing.