Supratim Bose, Neha Poddar, Swrajit Nath Sharma, Swapnendu Deb, Tanushree Mondal, Arindam Banerjee
membrane disruption along with reactive oxygen species (ROS) generation. The biofilm inhibition and mature biofilm destruction capabilities of self-assembled AP1 were observed against MRSA due to the combined effect of the reduction competency of extracellular polymeric substances (EPS) and planktonic cytolysis. This subsequently corroborated the hydrogel's application as an anti-infective surface-coating biomaterial. The MTT assay with eukaryotic mammalian cells (HEK-293, NKE, HaCaT) and haemolytic assay convincingly substantiated the biocompatibility of the self-assembled amphiphilic peptide, emphasizing its therapeutic potential as an antibacterial agent in biomedicine.