Petr Pospíšil, Vladimir Motornov, Ondřej Michal, Lucie Šálková, Soňa Boháčová, Tomáš Slanina, Ján Tarábek, Blanka Klepetářová, Petr Beier
groups are sequentially converted into trifluoromethyl radicals, enabling high-yielding transformations under mild conditions. The protocol exhibits excellent functional group tolerance and is applicable to the late-stage trifluoromethylation of pharmaceuticals, amino acids, and nucleosides. Mechanistic studies support a photoinitiated radical pathway and reveal the full utilization of the Cu(iii) species. The results presented advance the use of copper-mediated strategies for the sustainable incorporation of fluorine into complex molecules.