Development of novel salicylic acid derivatives with dual anti-inflammatory and anti-arthritic potentials: synthesis, <i>in vitro</i> bio-evaluation, and <i>in silico</i> toxicity prediction with molecular modeling simulations

toxicity predictions were conducted, demonstrating a safer profile compared to the utilized drugs. Additionally, docking simulations were performed for the most active derivatives, revealing higher binding affinities, supported by hydrogen bonding, arene-cation interactions, and hydrophobic interactions.