Enantioselective polar [2σ + 2π] cycloadditions of bicyclo[1.1.0]butanes and <i>ortho</i> -quinone methides enabled by chiral phosphoric acid catalysis

Lun Xu, Qin Zhong, Yi Zhou, R. LIU, Xian Sun, Xiao-Yu Liu, Yong Qin, Hao Song

原始摘要（英文原文）· Original abstract

We report a chiral phosphoric acid-catalyzed polar [2σ + 2π] cycloaddition of BCBs with o -QMs. This method efficiently constructs spiro-BCHs bearing vicinal tertiary–quaternary stereocenters with excellent atom economy and high enantioselectivity.

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