◆ RSC Medicinal Chemistry2026-01-01· Downregulation and upregulation
Exploring pyrazoline-thiophene hybrids as CDK2 inhibitors: synthesis, mechanism, biological studies, and computational insights
Heba M. Abosalim, Tarek Elmoselhy, Nabaweya Sharafeldin, Mohamed S. Nafie, Mohamed K. Diab, Mervat H. El‐Hamamsy, Haytham O. Tawfik
原始摘要（英文原文）· Original abstract
Novel pyrazoline-linked thiophenes were synthesized as anticancer agents. Lead compound 4p showed sub-micromolar cytotoxicity, induced CDK2-mediated apoptosis and cell-cycle arrest, and reduced tumor burden in vivo with low toxicity.