Kupffer cell M2-like polarization increases liver metastatic burden <i>via</i> the uptake of exosomal KRAS mutant protein from hypoxic colorectal carcinoma cells
Yu You, Zhihao Feng, Jiao Lu, Jie Xu, Ke You, Fuyao Liu, Tianzhu Wu, Hua Song, Zuojin Liu
原始摘要（英文原文）· Original abstract
the hyperactivation of AKT signaling, establishing this axis as a key mediator of colorectal cancer liver metastasis. Pharmacological inhibition of AKT effectively disrupts this immunosuppressive reprogramming, proposing targeted AKT blockade as a promising strategy to intercept the metastatic niche in CRC patients.