An <i>in vitro</i> organ-on-chip model for studying neuron–keratinocyte interactions in sensory response through electrophysiology

model using iPSC-derived sensory neurons and keratinocytes in MEA-integrated microfluidic chips. Neurons expressed nociceptor markers, showed TRPV activity, and formed contacts with keratinocytes. Stimuli evoked electrophysiological responses, highlighting neuron-keratinocyte interactions relevant to pruritus, pain, and skin disorders, supporting therapeutic development.