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◆ Dalton Transactions2025-10-06· Prodrug

Fluorophores to fighters: BODIPY-metal complexes as next-gen anticancer prodrugs

Twara Kikani, Krutika Patel, Sonal Thakore

原始摘要(英文原文)· Original abstract
). Boron-dipyrromethene (BODIPY) dyes are a class of fluorophores that serve as promising PSs with excellent light-activated reactive oxygen species (ROS) generating capacity (for PDT) and light-to-heat conversion (for PTT) causing the thermal ablation of cancer cells. Conjugating a metal-based drug along with a PS and a targeting ligand to design a prodrug acts as a "magic packet" to target various cancers. This review elaborates the advances in the development of metallo-prodrugs adorned with a BODIPY cage as cancer theranostics. It highlights the engineering marvel of constructing prodrugs with high specificity and organelle-targeting ability.
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