Puzhen Hui, Fengwu Xu, Huilin Zheng, Shankun Yao, Yuncong Chen, Xiaoxia Gu, Zijian Guo
lipid droplet (LD)-mediated pathways remains challenging. Herein, an LD-specific targeting Pt(II) complex was designed to address this limitation by directly inducing sufficient lipid peroxidation (LPO) accumulation, offering a novel platform for synergistic ferroptosis-apoptosis cancer therapy. This work provides a novel anticancer platform using photoactivated platinum complexes to concurrently trigger dual cell death pathways.